TNYL PEPTIDE FUNCTIONAL CHITOSAN-G-STEARATE CONJUGATE MICELLES FOR TUMOR SPECIFIC TARGETING


Induced pluripotent stem cell-derived mesenchymal stem cells deliver exogenous miR-105-5p via small extracellular vesicles to rejuvenate senescent nucleus pulposus cells and attenuate intervertebral disc degeneration

Abstract Background Mesenchymal stem cell-derived small extracellular Shirt vesicles (MSC-sEVs) have emerged as a promising new therapeutic strategy for intervertebral disc degeneration (IVDD).However, the drawbacks of MSCs, including their invasive access, the donor age, and their limited proliferative capacity, hinder the quantity and quality of

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